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Biological Chemistry of Arsenic, Antimony and Bismuth

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  • Author(s)Hongzhe Sun
  • Edition1
  • Published17th December 2010
  • PublisherJohn Wiley & Sons (UK)
  • ISBN9780470713907
Arsenic, antimony and bismuth, three related elements of group 15,
are all found in trace quantities in nature and have interesting
biological properties and uses. While arsenic is most well known as
a poison - and indeed the contamination of groundwater by arsenic
is becoming a major health problem in Asia - it also has uses for
the treatment of blood cancer and has long been used in traditional
chinese medicine. Antimony and bismuth compounds are used in the
clinic for the treatment of parasitic and bacterial infections.

Biological Chemistry of Arsenic, Antimony and Bismuth is
an essential overview of the biological chemistry of these three
elements, with contributions from an international panel of
experts. Topics covered include:



  • chemistry of As, Sb and Bi

  • biological chemistry of arsenic

  • biological chemistry of Sb and Bi

  • arsenic and antimony speciation in environmental and biological
    samples

  • arsenic in traditional chinese medicine

  • arsenic in aquifers

  • biomethylation of As, Sb and Bi

  • uptake of metalloids by cells

  • bismuth complexes of porphyrins and their potential in medical
    applications

  • Helicobacter pylori and bismuth

  • metabolism of arsenic trioxide in blood of the acute
    promyelocytic leukemia patients

  • anticancer properties of As, Sb and Bi

  • radio-Bi in cancer therapy

  • genotoxicity of As, Sb and Bi

  • metallomics as a new technique for As, Sb and Bi

  • metalloproteomics for As, Sb and Bi


Biological Chemistry of Arsenic, Antimony and Bismuth
conveys the essential aspects of the bioinorganic chemistry of
these three elements, making this book a valuable complement to
more general bioinorganic chemistry texts and more specialized
topical reviews. It will find a place on the bookshelves of
practitioners, researchers and students working in bioinorganic
chemistry and medicinal chemistry.

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