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The Developing Human Brain

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  • Author(s)Floyd Harry Gilles / Marvin D. Nelson
  • SubtitleGrowth and Adversities
  • Edition1
  • Published30th March 2012
  • PublisherJohn Wiley & Sons (UK)
  • ISBN9781908316417

Growth and Adversities

Clinics in Developmental Medicine

? Well over 200 illustrations, many in colour

? Co-authored by two experts in neuropathology and

? Takes a quantitative approach to brain growth in weight,
gyrus formation, myelination, and spectroscopy of the developing

? The only book in this field to include chapters in
angiogenesis, fetal behaviour, and reactions to chronic

This book is about human brain development, focusing on the last
half of gestation and the neonatal and infant periods. These
periods bring the greatest risk for the acquisition of childhood
functional neurologic deficits, including cerebral palsy,
developmental delay and intellectual disability. Section 1 covers
typical development, including growth in brain weight, ventricular
surfaces, gyral development, myelinated tract development, magnetic
resonance spectroscopy, and angiogenesis, all serving as reference
points for section 2, which deals with common acquired brain
abnormalities, some of which are often underemphasized or
overlooked. The topics in section 2 include retrocerebellar cysts,
abnormal events in fetal brain, white-matter abnormalities, lesions
of gray and white matter, hemorrhage, ventriculomegaly and
hydrocephalus, late expressions of fetal brain disease, and
reactions of the developing brain to chronic disease. Between
sections 1 and 2 is a chapter on embryonic and fetal physiologic
reactions to external stimuli. Where appropriate, the authors have
combined pathologic with neuroimaging examples to help the reader
better understand the neuroimages that they encounter.

Much of the information in the book is based on data from the
National Collaborative Perinatal Project, still the only large
autopsy survey of late fetal brain lesions.


Developmental neurobiologists, neuroscientists,
paediatricians, neuropathologists, pediatric neuroradiologists,
pediatric neurologists, neonatologists, perinatologists.

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